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Hematologic Malignancies • Medical Oncology • Leukemia • Myeloma • NCI-CCC Tumor Board Question • Mayo Clinic • NCI-CCC Myeloma Tumor Board Question
What is your preferred up-front treatment for transplant-eligible patients with primary (de novo) plasma cell leukemia?
Answer from: Medical Oncologist at Academic Institution
To some extent, it really will depend on how aggressively the disease is behaving. Most PCL cases are quite aggressive and need urgent therapy. For an extremely fit individual who is usually in the inpatient setting, I opt for VD-PACE (usually the IMiD is not available quickly). I will perform a TTE...
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Answer from: Medical Oncologist at Academic Institution
Agreed with @Ben Derman on all fronts, including considering Dara-KRd after a cycle of inpatient chemo-based induction... and venetoclax with t(11;14) for any relapse or refractoriness. We had initially been a bit apprehensive that venetoclax would interfere with stem cell collection, but so far it ...
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Medical Oncologist at Mayo Clinic Rochester
@Ben Derman and @Rahul Banerjee, any thoughts on w...
@Ben Derman and @Rahul Banerjee, any thoughts on w...
Medical Oncologist at University of Washington, Fred Hutchinson Cancer Research Center
Excellent question! I'll respond with an EXCELLENT...
Excellent question! I'll respond with an EXCELLENT...