What is your preferred up-front treatment for transplant-eligible patients with primary (de novo) plasma cell leukemia?

To some extent, it really will depend on how aggressively the disease is behaving. Most PCL cases are quite aggressive and need urgent therapy. For an extremely fit individual who is usually in the inpatient setting, I opt for VD-PACE (usually the IMiD is not available quickly). I will perform a TTE...

Agreed with @Dr. First Last on all fronts, including considering Dara-KRd after a cycle of inpatient chemo-based induction... and venetoclax with t(11;14) for any relapse or refractoriness. We had initially been a bit apprehensive that venetoclax would interfere with stem cell collection, but so far...