What is your preferred way of administering nivolumab/ipilimumab in GI cancers?

Nivo 3 + Ipi 1 Q2W x3 then Nivo alone? Or Nivo 3 Q2W & Ipi 1 Q6W until POD or toxicity? Or other?

1 Answer

Mednet MemberInvited Expert

Medical Oncology · University of Pittsburgh School of Medicine

Answered on

Thanks for the question.

My preference would be Nivo 3 Q2W & ipi 1 Q6W due to the more favorable toxicity profile seen in the first-line CheckMate-142 trial (Lenz et al., PMID 34637336) compared to CheckMate-142 that was conducted in refractory setting (Overman et al., PMID 29355075).

Thanks

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