What is your protocol for transitioning to oral anticoagulation post-thrombolysis for pulmonary embolism?
1
1 Answers
Mednet Member
Pulmonology · Washington State University Floyd College of Medicine
My answer has multiple parts.
"Thrombolysis" is not all the same. As studied in stroke treatment, alteplase causes marked fibrinogen depletion and coagulopathy (prolonged PT, aPTT), whereas tenecteplase doesn't so much (Huang et al., PMID 26514192).
So, if alteplase was used (systemic or reduced cathe...