Would you consider a third course of radiation in a patient with a WHO 3 astrocytoma who has previously received a fractionated course followed by fSRS many years later?

After a long interval such as 10 years, some recovery of normal brain tolerance is believed to occur, although the degree of recovery is not precisely known. Many radiation oncologists assume partial recovery of approximately 50-70% of prior tolerance when estimating reirradiation safety, but this i...