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What would be the targets and dosing for a patient with p16+ unilateral neck disease and a small basaloid SCC of the BOT found after diagnostic tonsillectomy and BOT resection?

2 Answers
Mednet Member
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Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

While detailed, often these questions are not detailed enough, and so I try to generalize and read between the lines to think what the specific question might be.

The nuances are:

  1. Is the question p16+/basaloid SCC different from HPV+? The short answer is no.
  2. What is a diagnostic tonsillectomy and BO...

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Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · University of Michigan
Answered on · Updated on

While non-oropharyngeal mucosal basaloid sq.c.ca is aggressive and associated with poor prognosis, in OPC it is HPV+ in the majority of cases, like the current case, and has favorable outcomes, similar to the common HPV+ non-keratinized squamous cell carcinoma (Chernock et al., PMID 20236687). I wou...

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