What is your starting dose of ponatinib for CML?

The standard starting dose for ponatinib is 45 mg. That being said, many clinicians lower the dose to 30 mg or 15 mg once a response is achieved in an effort to lower the rates of adverse events. The ongoing OPTIC study is evaluating if it is safe/effective to start at lower doses. An interim analysis of this study showed decreased adverse events in the two low doses (15 mg and 30 mg) compared to 45 mg. For patients without a T315I mutation, starting at lower doses is associated with good rates ...