What is your surveillance strategy in patients with brain metastases who are getting systemic therapy?
How often are you scanning the brain and what is your trigger to treat?
Answer from: Radiation Oncologist at Academic Institution
Generally, I’d consider a repeat MRI every 2-3 months, earlier if warranted. Assuming no evidence of disease progression for 1 or 2 years, I’d consider every 3-6 months.
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Answer from: Radiation Oncologist at Community Practice
I would agree that every 3 months is reasonable. These are patients who could have a long/deep response, so would continue to monitor for years out.
As far as what triggers to treat, I will be interested to see what others would say, but I have a low threshold to treat once I see progressio...
Answer from: Radiation Oncologist at Academic Institution
I presume that the question is talking about patients with brain metastases treated with IT alone (meaning no history of radiation). This has been evaluated in Melanoma (best response with ~50-55% ORR with Ipi/Nivo here: Tawbi et al., PMID 30134131) and here (Long et al., ASCO Annual Meeting 2021), ...