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What is your treatment approach for MAG antibody associated polyneuropathy?
If using rituximab, how often are you treating the patient? E.g., every 6 months or alternatively, do you use a serological test like B cell number, MAG titers, or IgM levels to guide retreatment timing?
Answer from: at Academic Institution
When patients have a classic Distal acquired demyelinating sensory (DADS) Neuropathy phenotype (by clinical +/- EDX criteria), typically an SPEP/IFE is checked first, and if an IgM monoclonal gammopathy is observed, then I typically check MAG antibodies at that point (if clinical and EDX features ar...
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