I would start by confirming that I feel comfortable with their biopsy results:1) ensuring that there appears to be adequate sampling of the prostate on biopsy,2) obtaining an MRI to make sure there is not a concerning appearing lesion that was not sampled (for instance, anterior disease),3) would al...

My home institution published on this scenario considering the non-specific nature of an elevated PSA.   In summary, these patients appear to act similar to high risk disease and should likely be treated as such (long course ADT+radiation). Gestaut et al. Clinical Genitourinary Cancer 20...