What medications would you have a patient avoid with an IgE mediated reaction to cyclobenzaprine?
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1 Answers
Mednet Member
Allergy & Immunology · Harvard Medical School
The mechanism of immediate hypersensitivity to cyclobenzaprine is likely MRGPRX2-mediated rather than IgE-mediated. MRGPRX2 is a G-protein coupled receptor (GPCR) predominantly expressed in human mast cells. Upon activation, MRGPRX2 triggers mast cell degranulation and anaphylactic reactions. MRGPRX...