One of the complications inherent in using AEDs in anybody with epilepsy syndrome or neurotypical people with seizures is bone loss. It is especially important to look at their early loss of bone mass. I check for vitamin D levels even in very young patients. I might even do DEXA scans. I'm very proactive in looking for bone density and considering whether they might need replacement treatment.
We also have to think about the dosing of these medications for people who have developmental disabilities and small stature. Consider using smaller doses or such and whether their metabolism is different. We also need to screen the medication list and make note of other drugs they might be taking for other things.
Another thing that I do in terms of monitoring is to monitor the outcomes. The one thing I do to monitor people with lifelong seizures is online seizure tracking which is especially helpful in patients who are highly refractory to treatment. I'm very biased towards using an online seizure calendar to help me guide and follow people objectively, otherwise, it's very hard to determine if the medication is actually having the intended effect. I use seizuretracker.com because it’s HIPAA compliant and it’s easy to do for the caregiver. This way I can see the time of the seizure and the length of the seizure, and I can follow them serially to help determine whether the treatment I recommended was successful.