What monitoring would you pursue in a female patient with repeatedly very high titer centromere antibodies but no clinical symptoms of systemic sclerosis or other connective tissue disease?

For an asymptomatic patient with very high–titer anticentromere antibodies (ACA), monitoring should focus on early detection of systemic sclerosis (SSc) and related organ involvement, as higher ACA levels are associated with increased risk of progression. Risk stratification is informed by the devel...