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What neoadjuvant chemotherapy do you suggest for a rapidly growing triple-negative breast cancer?

Would you give pembrolizumab with chemotherapy or just chemotherapy? The patient had a history of mantle radiation several years ago.
2 Answers
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Medical Oncology · Ohio State University
Answered on

If the patient has non-metastatic, operable triple-negative breast cancer that is at least 2 cm in diameter or positive for axillary lymph node metastases, I would use the KEYNOTE-522 regimen (1 year of pembrolizumab in combination with 4 cycles of neo-adjuvant paclitaxel, carboplatin followed by 4 ...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Duke University
Answered on

As with any rapidly growing cancer, we employ the most effective treatment in a timely manner. In the case of a localized triple-negative breast cancer (TNBC), effective systemic neoadjuvant therapy is indicated. The start of systemic neoadjuvant therapy needs to follow three essential steps:

  1. Confir...

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