What non-taxane chemotherapy can you partner with trastuzumab/pertuzumab for HER2+ breast CA if neuropathy either at baseline or with treatment becomes prohibitive?

Topics: Breast Cancer • Medical Oncology

What would you use either in adjuvant setting or in metastatic setting?

Answer from: Medical Oncologist at Academic Institution

For less neuropathic agents there are safety/efficacy data from the PHEREXA trial combining capecitabine with pertuzumab and trastuzumab (Urruticoechea et al JCO 2018). We also presented data on using gemcitabine with pertuzumab and trastuzumab in a small phase 1/2. (Soliman et al JCO 2016). T...

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Medical Oncologist at Hawaii Oncology Inc-Kuakini
Is there data for HP without cytotoxic chemo in th...

Medical Oncologist at H Lee Moffitt Cancer Center, University of South Florida
There is data from the PERTAIN trial using an AI p...

Answer from: Medical Oncologist at Community Practice

I just read this in practice update and though relevant so sharing to help answer your question In the randomized, phase III, MARIANNE trial, the authors evaluated the efficacy of trastuzumab emtansine (T-DM1), T-DM1 plus pertuzumab, and trastuzumab plus a taxane in 1095 patients with HER2-po...

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Medical Oncologist at Northwestern Medicine Cancer Center at KishHealth
Thank you. That was very helpful.

Medical Oncologist at Oncology & Hematology Specialists
👍👍

Medical Oncologist at H Lee Moffitt Cancer Center, University of South Florida
Thank you Muhammed. Although TDM1 is a nontaxane t...

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