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Topics:
Rheumatology • Systemic lupus erythematosus • Hydroxychloroquine • Cardiology • Cardiac Electrophysiology
What parameters would you use to decide whether to stop hydroxychloroquine in a patient whose lupus is well controlled but is found to have a prolonged QT interval on routine EKG?
Answer from: at Academic Institution
This is an excellent question for which there is no one-size-fits-all answer. The first question is how prolonged the QT is, and if there is another drug they are on that is contributing to the prolonged QT. Obviously, it is important to avoid prescribing other medications that prolong the QT. It is...
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Answer from: at Community Practice
This scenario requires a discussion with the patient involving shared decision-making.On the one hand, the numerous benefits of taking HCQ in SLE are numerous (fewer CV events, less DMII, fewer infections and cancers, increased remission rates, reduced SLE flares, and it is the only drug proven to p...
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at Arthritis and Rheumatology Clinic of Northern Colorado
Very helpful information. Thanks very much!
Very helpful information. Thanks very much!
Answer from: at Academic Institution
Great comments by Dr. @Gilkeson & Dr. @Thomas! As alluded to by Dr. @Thomas, I think a lot of the concern re QTc prolongation with hydroxychloroquine came after it was studied in COVID-19 patients at much higher dosages than we use in Rheumatology. For example, the RECOVERY trial during COVID us...