What patient factors influence your decision between prescribing oral pre-exposure prophylaxis and long-acting injectable PrEP for HIV prevention?  

First of all, is the patient generally compliant? Most of the time we use oral, once-daily agents for PrEP, but we do have some individuals on every-2-month injectable Cabenuva now. We do not have anyone on every-6-month lenacapavir, since the VA does not offer it. Have a discussion with the patient...

In our system, we have IM cabotegravir.  Lenacapavir is covered by Medi-Cal, but is not on our formulary yet. In our publicly funded, managed care system, we are more cost-conscious than most, and we tend to prefer oral, generic FTC/TDF. However, when patients ask for IM HIV PrEP, we do our b...