What patient factors most strongly influence your decision to start biologic agents in mild cognitive impairment?

1.Absence of need for anticoagulants ( this is exclusionary)

2. Absence of APOE e4 homozygosity (although we do treat e4 homozygotes, but with much greater precautionary measures - especially the dosing protocol)

3. High functional ability, and adherence to healthy lifestyle measures (exercise, diet, cognitive and social activity),

4. Good comprehension of the cost benefit ratio of treatment and likelihood of adherence to the protocol, including response to adverse events during treatment.