What radiation dose would you use when giving definitive chemoradiation for inoperable rectal cancer with extensive invasion into gluteal musculature?

A rectal cancer this aggressive is not easy to control. Surgeons tell me the surgical options are not promising. Assuming this is a new diagnosis, I would employ a total neoadjuvant approach. I would start with chemotherapy in this case (not 5x5 followed by chemo a la RAPIDO). After 4+ months of che...

Many patients with locally advanced rectal cancers may be operable with multi-specialty input (GI surgery, urology, plastic surgery, etc.). When I see a patient with locally advanced inoperable rectal cancer, the first decision point is whether the patient is suited for definitive treatment with cur...