What references do you use for multi-parametric MRI delineation of the GTV in prostate cancer for prostate nodule?

In FLAME, the boost volume was the GTV on mpMRI as judged by the treating physician without any formal contouring guidelines (Kerkmeijer et al., PMID 33471548). There were differences in MRI protocols and physician judgement resulting in significant differences in tumor volumes between centers (van ...

This is an important question because FLAME did something quite remarkable in oncology: demonstrate a DFS benefit *without* increasing toxicity. We would, of course, want all eligible patients to benefit from this result and approach. But even radiologists need a lot of training to accurately identi...