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What regimen/constraints do you use for moderately hypofractionated salvage / post-prostatectomy radiation?

Any comments/recommendations regarding the UK approach using 52.5Gy in 20 fractions (Chin et al., IJROBP, 2020)?
1 Answer
Mednet Member
Radiation Oncology · University of Wisconsin-Madison
Answered on · Updated on

Current NCCN guidelines continue to recommend prescribed doses for adjuvant/salvage post-prostatectomy RT of between 64 and 72 Gy using standard fractionation. These regimens are known to be safe and effective. However, substantial non-randomized outcomes data from numerous institutions, including our own, also indicate that moderate hypofractionation regimens can be safe and efficacious as well, when guided by appropriate consideration of EQD2 estimates.

The rapid accrual experienced for the ran...

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