What role, if any, should Ki-67 play in decision making about the role of adjuvant radiotherapy in patients who meet CALGB 9343 entry criteria?

CALGB /PRIME2 study didnt look at Ki67 but did notice grade 3 disease had higher risk of recurrence

The Canadian study retrospectively did IHC using K167 14% as cut off for Luminal A vs. Luminal B classification and did notice that luminal B had higher IBTR than luminal A, although could not distingu...