What salvage EBRT dose would you recommend for radiation-naive patients with Hodgkin's Lymphoma who are refractory to chemotherapy and immunotherapy and decline to undergo transplant?

Just for fun, I suggest you find Stanford's Henry Kaplan's first book on Hodgkin's Disease, plus Red Journal and Cancer articles from Harvard Joint Center's Samuel Hellman on what XRT alone can accomplish for all stages before writing off this case (yes-we do not yet have any details) as palliative....

I think this largely depends on two factors: stage at diagnosis and stage at relapse. Historically, ~70% of patients with stage I-II HL were cured with RT alone. Most patients had supradiaphragmatic disease. The most effective treatment for such patients was initial treatment with a mantle field to ...

Sorry, but more information is needed to answer this question. What was the stage at diagnosis, sites of disease at diagnosis, date of diagnosis, extent of disease presently, systemic symptoms, age of the patient, and general medical condition?

This is likely a palliative scenario, thus, I would try to limit toxicity and time spent on treatment.

30-36/3 appears reasonable, in my opinion.

There is retrospective data for RT salvage for early-stage localized disease if it was not given upfront. Favorable predictors include a longer time interval from initial treatment. In the local recurrence scenario, I would go to about 36-40 Gy absent chemotherapy, perhaps a bit higher to 45 Gy if b...