A drug holiday (drug sabbatical) is given to reduce the likelihood of an atypical femur fracture. Such fractures have characteristic x-ray appearances and are found from below the lesser trochanter to the supracondylar flare of the distal femur. While the overall incidence of these fractures is low,...

Dr. @Stephen Honig has provided an excellent response and describes a well-thought out approach to drug holiday duration. I fully agree with his recommendations. I would add that it is important to re-assess patients regularly during the period of the drug holiday to determine if there has been an i...