What supportive care measures do you prioritize to manage or prevent toxicity in patients receiving Dato-DXd?  

My supportive care approach is centered around early identification and management of interstitial lung disease (ILD) and mucositis, both of which were observed in the TROPION-Breast01 trial. Twelve patients (3.3%) in the Dato-DXd arm had adjudicated drug-related ILD/pneumonitis. I routinely obtain ...

It is important to counsel regarding the prophylactic use of steroid mouth rinse and good oral care to mitigate and prevent stomatitis. Fortunately, ILD is very uncommon. Ocular toxicity, such as dry eye, is generally low grade, and using eye drops for lubrication is often helpful.