What systemic therapy would you offer a postmenopausal women with oligometastatic sternal disease which developed while on tamoxifen?

Topics: Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • University of Utah

Provided the sternal lesion was low volume and treated with curative intent and patient has been on tamoxifen for < 5 years, would you switch to AI or move on to AI+CDK 4/6 inhibitor?

Answer from: Medical Oncologist at Community Practice

For an isolated sternal metastasis, I would normally refer to radiation oncology for focused radiation, and I would change her hormonal therapy to an aromatase inhibitor, as these patients can have very long survival times. Some patients survive longer than a decade. (Milano MT et al). Having a...

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Medical Oncologist at Warren Alpert Medical School of Brown University
Since the development of an isolated sternal metas...

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