What systemic therapy would you offer for a local, unresectable relapse of a mixed acinar neuroendocrine carcinoma of the pancreas?
2 Answers
Mednet Member
Medical Oncology · UH Seidman Cancer Center, Case Western Reserve University
This is a very interesting question. I agree with the overall discussion with some points that need to be clear:
- Did the pathology show mixed acinar and NEC with >30% of each component? or just acinar with NE features? I agree the data about MANEC is very limited and exclusively retrospective.
- What ...
Mednet Member
Medical Oncology · UAB, Birmingham
MANEC's are a unique and extremely rare entity and hence, guidelines regarding management are limited. Their prognosis is poor due to aggressive tumor biology.
Management can be extrapolated from high-grade neuroendocrine carcinoma of the GI tract and pancreatic adenocarcinoma in the management of t...