What molecular testing are you ordering in the adjuvant and neoadjuvant setting for GI cancers?
Do you routinely do universal NGS testing? Or only order MMR and pik3ca in colon cancer?
2 Answers
Mednet MemberInvited Expert
Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
Answered on
The answer depends on the specific GI cancer and the clinical setting (resectable vs. metastatic). Universal NGS is not recommended for resectable non-metastatic colon cancer. MMR/MSI testing and somatic PI3K pathway alterations (including PIK3CA) are recommended for stage II–III disease. Comprehens...
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Mednet MemberInvited Expert
Medical Oncology · University of Washington, Fred Hutchinson Cancer Research Center
Answered on
In colon cancer, I order MMR by ICH and MSI by NGS. I also order PIK3CA, etc., testing. In pancreatic cancer, I often get NGS testing given the high chance of recurrence.
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