What third line treatment do you consider for a patient with metastatic pancreatic cancer with good functional status and no targetable mutations after progression on FOLFIRINOX and gemcitabine/nab-paclitaxel?

Sadly, there is absolutely no "standard" option in this space, as no trials have demonstrated any meaningful benefit.

I personally would not just "try" a therapy - and I would especially not just "try" an immune checkpoint inhibitor, as these, as single agents have shown no benefit at all (if the tu...

Agree with a thorough look for an actionable alteration and/or a phase I trial if possible.

There may be a very modest benefit of nal-Iri in PC after FOLFIRINOX according to a recent retrospective study, so previous irinotecan may not always mean there is no benefit from Nal-Iri based therapy. Would...

Napoli-1 trial.

Consider Liposomal Irinotecan with 5FU, Leucovorin.