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What topical and oral therapies do you prescribe for patients with recalcitrant melasma?

1 Answer
Mednet Member
Dermatology · Forefront Dermatology
Answered on

This is my Melasma algorithm:

  1. Hydroquinone triple cream qhs x 6 months + azelaic acid in the AM + tinted sunscreen
  2. Consider PO TXA (half of 650 mg tab bid), polypodium leucotomos bid (heliocare)
  3. Maintenance: stop hydroquinone and switch to compounded TXA/kojic/tretinoin combo cream qhs + vitamin C/azelaic in the morning
  4. Cysteamine cream a few times weekly at bedtime
  5. Add on microneedling to topicals before higher-risk things (peels, lasers)

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