Topics:
Neuro-Oncology • Pediatric Oncology
What treatment do you offer to a pediatric patient with an optic pathway glioma with a BRAFV600E mutation who progressed despite receiving conventional chemotherapy, BRAF/MEK inhibitors, and radiation therapy?
Answer from: at Academic Institution
These cases are often tough, especially in this location. I assume the patient does not have NF1? Most patients with NF1 will not have concurrent specific BRAF mutations. One alternative therapy is a combination of bevacizumab and irinotecan (published by Gururangan et al). Also, if the patien...
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