What treatment do you recommend for painful large plaques of leiomyomas on the back of a patient with HLRCC syndrome when lesions are too large for excision?   

Depending on the extent of discomfort, surgery may be required for debilitating leiomyoma-associated pain. In some cases, a larger exophytic nodule(s) can be isolated as the lesion(s) that are most painful and selectively excised, but broad segmental involvement is common in HLRCC, particularly on t...