What treatment options are there for uremic pruritus in an elderly patient with risk of sundowning? How can treatments be combined or escalated?  

Uremic pruritus is increasingly recognized as a multifactorial condition involving peripheral neuropathy and immune dysregulation, particularly upregulation of type 2 cytokine pathways. Dysregulated opioid signaling further contributes to itch amplification. Accordingly, κ-opioid receptor agonists,...