What treatment would you consider for metastatic urachal carcinoma following progression on FOLFOX and FOLFIRI?

Topics: Genitourinary Cancers • Bladder Cancer • Medical Oncology • NCI-CCC Tumor Board Question • UCSF • NCI-CCC GU Tumor Board Question

Molecular profiling revealed no targetable alterations, however tumor mutational burden was >10 mut/Mb.

Answer from: Medical Oncologist at Community Practice

Metastatic urachal adenocarcinoma is a challenging disease to treat with significant unmet needs. Initial therapy replicates therapy for metastatic colorectal adenocarcinoma and may include FOLFOX, FOLFIRI or FOLFOXIRI potentially combined with bevacizumab. Salvage therapy may include 1) trials (gui...

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Medical Oncologist at University of Washington School of Medicine
Great comments by the expert @Guru Sonpavde; regar...

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