What workup do you suggest for patients with concern for opsoclonus-myoclonus syndrome?

Opsoclonus-myoclonus syndrome (OMS) is characterized by fast and irregular multidirectional eye movements combined with generalized myoclonus and often ataxia. The common etiologies include paraneoplastic, autoimmune, and infectious/parainfectious causes. The approach in children and adults is different, given a significantly higher likelihood of paraneoplastic etiology, and specifically neuroblastoma, in children. In contrast, in adults, neuroblastoma is rare, and paraneoplastic causes secondar...