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What would be your approach to the treatment of limited stage extrapulmonary small cell carcinoma of the nasopharynx with bilateral cervical lymphadenopathy?

Specifically, with respect to sequencing of chemotherapy, dosing and target delineation- would you cover elective areas like standard NPC fields or gross disease only?
2 Answers
Mednet Member
Mednet Member
Radiation Oncology · Michigan Healthcare Professionals, PC
Answered on · Updated on

Rare entity and not a whole lot of evidence to base treatment decisions on.

That being said, at least make sure a brain MRI has been completed (I know this seems obvious, but just in case).

If the patient was in good shape, I would treat with concurrent CRT based on a series out of Japan. Whether to ...

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Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · University of Michigan
Answered on

Agree with Dr. @Dr. First Last, esp regarding no need for PCI. Extrapulmonary tumors, including small cell, do not drain to the brain unless there are lung metastases.

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