What would be your preferred adjuvant regimen for ampullary carcinoma (pancreatic histology) in patient with pre-existing neuropathy?

The approach to adjuvant therapy for ampullary cancer is always controversial. Few studies have addressed this directly. The EORTC trial reported in 1999 evaluated 5-FU and radiotherapy vs observation in pancreatic and ampullary cancer and showed no benefit in the ampullary subset (Ann Surg 1999).

in...

Use gemcitabine and capecitabine.