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Topics:
Radiation Oncology • Gastrointestinal Cancers • Rectal Cancer • Medical Oncology • Colorectal Cancer
What would be your radiotherapy plan for an overall stage IIA, low-lying, MMRd rectal adenocarcinoma to try to avoid APR?
The tumor is 4 cm from the anal verge. How would you construct your volumes/dose, and would you consider a boost up to 54 Gy?
Answer from: Radiation Oncologist at Academic Institution
For an MMRd rectal cancer, I would use immunotherapy! Very promising data from MSKCC suggesting upwards of 100% clinical complete response with dostarlimab alone, without the need for RT!
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