What would you choose as a first line therapy for a patient with CLL who is asymptomatic with Rai Stage 4 with bulky adenopathy and organomegaly?

Topics: Hematologic Malignancies • Medical Oncology • Leukemia • Hematology

Would it change your management if patient if IgVH mutated?

Answer from: Medical Oncologist at Academic Institution

A big discriminating feature here would be based upon age. For a patient who is fit and <65-70 years, IGHV mutated disease may be curable with fludarabine, cyclophosphamde, and rituximab therapy, first piloted by Michael Keating's group at MD Anderson Cancer Center. At a median follow up time pe...

Comments

Medical Oncologist at Hinsdale Hem/Onc Assoc
Thank you so much for the thoughtful response. Th...

Medical Oncologist at Hematology Oncology Medical Group of Orange County
The benefit of FCRover BR in this setting is low s...

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