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When and how do you approach prescribing viloxazine for patients with ADHD?

Have you ever prescribed it to patients already taking other psychiatric medications such as SSRIs, SNRIs, bupropion, or second-generation antipsychotics? How do you typically titrate it? How soon do you see clinical benefit? What informed consent points do you usually cover with the patient?
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Have you ever prescribed viloxazine to treat ADHD?

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5 Answers
Mednet Member
Mednet MemberInvited Expert
Psychiatry · Wayne State University School of Medicine
Answered on · Updated on

Viloxazine is a potent inhibitor of CYP1A2 and a weak inhibitor of CYP2D6 and CYP3A4. It should never be used within 2 weeks of an MAOI. I use significant caution when prescribing it with other psychotropic medications, as it can raise the levels of multiple other agents, including aripiprazole, dex...

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Mednet Member
Mednet Member
Psychiatry · Jersey Forensic Consulting
Answered on

Viloxidine (Qelbree) is actually one of my favorite medications for ADHD. It works especially well in that group of children (and adults) who I call the "chicken can't touch their rice people." You know, the patients with very mild neurodivergent traits that are not eligible for an autism diagnosis,...

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Mednet MemberInvited Expert
Psychiatry · Private Practice
Answered on

The hardest part with this medication is usually getting insurance approval since it is branded, and making sure it is not interacting with other medications.

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Mednet Member
Mednet MemberInvited Expert
Psychiatry · Siu Psychiatry
Answered on

I have prescribed viloxazine along with risperidone, several SSRIs, but not with SNRI or Wellbutrin. I agree with @Dr. First Last.

Practically, I have prescribed in cases of ADHD who are unable to take or tolerate stimulants or atomoxetine, or even swallow atomoxetine, because viloxazine can be open...

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Mednet Member
Mednet Member
Psychiatry · Private Practice
Answered on

This one breaks my heart! We all wished it worked better and had fewer interactions, but alas, that's not the case. There is a huge gap in this space, but unfortunately, it was not filled with this choice!

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