Topics:
Hematologic Malignancies • Pediatric Oncology • Medical Oncology • Bone Marrow Transplant • Hematology
When can defibrotide be discontinued before the 21-day treatment course is completed in a pediatric patient with SOS?
Do you always treat with the full 21-day treatment course, or can defibrotide be stopped if certain criteria are met sooner?
Answer from: at Community Practice
There is no data to support the 21-day use in everyone. Also, some patients might even need a longer course than the prescribed 21 days if manifestations are ongoing.
A good general rule of thumb would be to continue (provided no bleeding or other toxicities) for 3-5-7 days post resolutio...
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