When can defibrotide be discontinued before the 21-day treatment course is completed in a pediatric patient with SOS?
Do you always treat with the full 21-day treatment course, or can defibrotide be stopped if certain criteria are met sooner?
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Do you always treat SOS with defibrotide for the full 21-day course?
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1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Barnes-Jewish West County Hospital
Answered on
There is no data to support the 21-day use in everyone. Also, some patients might even need a longer course than the prescribed 21 days if manifestations are ongoing.
A good general rule of thumb would be to continue (provided no bleeding or other toxicities) for 3-5-7 days post resolution of ong...
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