When can defibrotide be discontinued before the 21-day treatment course is completed in a pediatric patient with SOS?

There is no data to support the 21-day use in everyone. Also, some patients might even need a longer course than the prescribed 21 days if manifestations are ongoing.

A good general rule of thumb would be to continue (provided no bleeding or other toxicities) for 3-5-7 days post resolution of ong...