When chemotherapy is indicated in early stage soft tissue sarcoma, would you prefer to use AD or AI?

I would start by bringing caution to the phrase, "when chemotherapy is indicated in early stage sarcoma." I assume you are asking about adjuvant chemotherapy, and will provide comments with that assumption. The role of adjuvant chemotherapy in resected soft tissue sarcomas remains controversial, and therefore the phrase when chemotherapy is indicated in early stage sarcoma is, in and of itself, a significant discussion within a multi-disciplinary team and the patient with many case specific factors to be considered. The decision to move forward likely depends on multiple factors including, but not limited to, location, margins, size, histology, grade, PS, and patient preference. The only sarcomas with clear, consistent evidence to support c...