When do you check for EPOR gene mutations in your workup for erythrocytosis, and if found, how do you manage it?

Only consider it in instances where there is a life-long (or at least long-term) erythrocytosis and there is no evidence of a secondary erythrocytosis. There is no role for ASA or HU in these instances. I generally do not use phlebotomy either, unless the hematocrit is extreme and the patient is sym...