When do you consider de-escalating therapy such as dupilumab in eosinophilic esophagitis?

It is first important to recognize that EoE is a chronic condition. In a patient whose EoE is successfully being treated (whether it be with PPI therapy, swallowed steroids, food elimination, or dupilumab), the disease will invariably become active again over time if therapy is stopped. This is why it is critical to explain to patients that EoE is a chronic disease and that the disease will recur if they go off treatment. This includes dupilumab. The question stem specifically mentions the possi...