When do you consider genetic testing for autoinflammatory diseases in patients with recurrent pericarditis and fever, particularly when symptoms are highly responsive to IL-1 blockade?

Yesterday ;-).

About 10% of patients with recurrent pericarditis have genes that may increase their risk of pericarditis. If you're already managing the patient with IL-1 inhibition, I would strongly encourage you to conduct genetic testing.

Just my 2 cents...

Genetic testing is relatively cheap when compared with our medications and biologics. For example, the Invitae immunodeficiency panel, which I frequently use, is about $200 in out-of-pocket cost last year without insurance, which I tell my patients.

However, in my experience, most of the patients I'...