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When do you consider more aggressive options for insomnia in patients with autism spectrum disorder if first line agents have failed?

Alpha agonists, trazodone, melatonin, and hydroxyzine are often tried but some patients continue to report symptoms. Which medications would you consider next?
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Which medications would you consider first for insomnia in autism spectrum disorder when first line agents have failed?

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2 Answers
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Psychiatry · Duke University
Answered on

Addressing insomnia in individuals with autism spectrum disorder (ASD) is considerably more complex than it may initially appear. Because ASD encompasses a wide range of cognitive, behavioral, and functional profiles, it is unrealistic to expect a single approach to work across the entire spectrum.

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Psychiatry · Siu Psychiatry
Answered on

Practically, I generally prescribe clonidine, trazodone, or mirtazapine depending on the case, always smallest effective dose. I avoid antipsychotics just for sleep due to long-term SEs. I work with children mostly, so none of the options above are my first choice due to their safety profile/limited...

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