When do you consider preoperative chemoRT v. chemotherapy in unresectable thymoma or thymic carcinoma?

I believe that the best systemic therapy for thymoma is anthracycline-based (e.g. cisplatin, doxorubicin plus cyclophosphamide (PAC)) as these regimens have historically about a 20-30% higher response rate than non-anthracycline regimens. As such concurrent radiotherapy is not permissible because of...