When do you consider testing autoimmune antibodies for axonal polyneuropathies without clear etiology?

Dr. @Dr. First Last gave an excellent summary of the clinical red flags that should trigger antibody testing in polyneuropathies. I would like to highlight that not all antibodies are pathogenic or cause the same phenotypes/clinical syndromes, therefore, I would like to break it down by antibody gro...

Testing for autoimmune antibodies in axonal polyneuropathies without a clear etiology is considered when the clinical picture, history, or associated features suggest an underlying immune-mediated or paraneoplastic process. Here’s when it would be reasonable to consider antibody testing:

1. Subacute...