When do you consider testing for anti-IgLON5 disease in patients with parkinsonism?

Anti-IgLON5 disease is a rare and intriguing entity with an expanding phenotype. It has features of both autoimmune (antibody against a cell adhesion molecule, response to immunotherapy in some cases) and neurodegenerative (tau deposition, gradual course) disorders. Unlike many other autoimmune pres...

I agree with the answer. In general, it is not very common to see parkinsonism as an isolated manifestation of anti-IGLON5. If I see a patient with parkinsonism, the clinical features that would make me think of anti-IGLON5 are new onset sleep-related problems that extend beyond just RBD, dysphagia ...