When do you consider testing for dihydropyrimidine dehydrogenase (DPD) for patients prior to treatment with 5-FU/capecitabine?
If you do test, do you have a preferred testing method?
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Do you test for DPD deficiency prior to adjuvant fluoropyrimidine-based chemotherapy for colorectal cancer?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
Answered on · Updated on
Happy to address this question! It is my practice to test for DPD deficiency in all patients who will receive a first treatment with a fluoropyrimidine agent (5-FU or capecitabine). My objective in doing this is to avoid infrequent but readily avoidable severe toxicities and deaths related to DPD de...
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